Depleting hepatitis B virus relaxed circular DNA is necessary for resolution of infection by CRISPR-Cas9

CRISPR-Cas9 systems can directly target the hepatitis B virus (HBV) major genomic form, covalently closed circular DNA (cccDNA), for decay and demonstrate remarkable anti-HBV activity. Here, we demonstrate that CRISPR-Cas9-mediated inactivation of HBV cccDNA, frequently regarded as the “holy grail”...

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Detalles Bibliográficos
Autores principales: Kostyushev, Dmitry, Kostyusheva, Anastasiya, Brezgin, Sergey, Ponomareva, Natalia, Zakirova, Natalia F., Egorshina, Aleksandra, Yanvarev, Dmitry V., Bayurova, Ekaterina, Sudina, Anna, Goptar, Irina, Nikiforova, Anastasiya, Dunaeva, Elena, Lisitsa, Tatiana, Abramov, Ivan, Frolova, Anastasiia, Lukashev, Alexander, Gordeychuk, Ilya, Zamyatnin, Andrey A., Ivanov, Alexander, Chulanov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972396/
https://www.ncbi.nlm.nih.gov/pubmed/36865089
http://dx.doi.org/10.1016/j.omtn.2023.02.001

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