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PD-L1 gene amplification and focality: relationship with protein expression

PD-L1 (CD274) amplification occurs in a small subset of malignancies and may predict anti-PD-1/PD-L1 immunotherapy responsiveness. We hypothesized that both copy number (CN) and focality of cancer-related PD-L1 amplifications impact protein expression, and, thus, analyzed solid tumors that underwent...

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Detalles Bibliográficos
Autores principales:	Jardim, Denis Leonardo, Murugesan, Karthikeyan, Elvin, Julia A., Huang, Richard S. P., Kurzrock, Razelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972417/ https://www.ncbi.nlm.nih.gov/pubmed/36849197 http://dx.doi.org/10.1136/jitc-2022-006311

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