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International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study

BACKGROUND: Acute exacerbations of asthma are common in children, however, treatment decisions for severe exacerbations are challenging due to a lack of robust evidence. In order to create more robust research, a core set of outcome measures needs to be developed. In developing these outcomes, it is...

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Autores principales: Gray, Charmaine S, Xu, Yao, Babl, Franz E, Dalziel, Stuart, Powell, Colin V E, Chong, Shu-Ling, Roland, Damian, Lyttle, Mark D, Fernandes, Ricardo M, Benito, Javier, Johnson, Mike, Yock-Corrales, Adriana, Santhanam, Indumathy, Schuh, Suzanne, Cheema, Baljit, Couper, Jenny, Craig, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972434/
https://www.ncbi.nlm.nih.gov/pubmed/36849194
http://dx.doi.org/10.1136/bmjresp-2022-001502
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author Gray, Charmaine S
Xu, Yao
Babl, Franz E
Dalziel, Stuart
Powell, Colin V E
Chong, Shu-Ling
Roland, Damian
Lyttle, Mark D
Fernandes, Ricardo M
Benito, Javier
Johnson, Mike
Yock-Corrales, Adriana
Santhanam, Indumathy
Schuh, Suzanne
Cheema, Baljit
Couper, Jenny
Craig, Simon
author_facet Gray, Charmaine S
Xu, Yao
Babl, Franz E
Dalziel, Stuart
Powell, Colin V E
Chong, Shu-Ling
Roland, Damian
Lyttle, Mark D
Fernandes, Ricardo M
Benito, Javier
Johnson, Mike
Yock-Corrales, Adriana
Santhanam, Indumathy
Schuh, Suzanne
Cheema, Baljit
Couper, Jenny
Craig, Simon
author_sort Gray, Charmaine S
collection PubMed
description BACKGROUND: Acute exacerbations of asthma are common in children, however, treatment decisions for severe exacerbations are challenging due to a lack of robust evidence. In order to create more robust research, a core set of outcome measures needs to be developed. In developing these outcomes, it is important to understand the views of clinicians who care for these children in particular, views that relate to outcome measures and research priorities. METHODS: To determine the views of clinicians, a total of 26 semistructured interviews based on the theoretical domains framework were conducted. These included experienced clinicians from emergency, intensive care and inpatient paediatrics across 17 countries. The interviews were recorded, and later transcribed. All data analyses were conducted in Nvivo by using thematic analysis. RESULTS: The length of stay in hospital and patient-focused parameters, such as timing to return to school and normal activity, were the most frequently highlighted outcome measures, with clinicians identifying the need to achieve a consensus on key core outcome measure sets. Most research questions focused on understanding the best treatment options, including the role of novel therapies and respiratory support. CONCLUSION: Our study provides an insight into what research questions and outcome measures clinicians view as important. In addition, information on how clinicians define asthma severity and measure treatment success will assist with methodological design in future trials. The current findings will be used in parallel with a further Paediatric Emergency Research Network study focusing on the child and family perspectives and will contribute to develop a core outcome set for future research.
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spelling pubmed-99724342023-03-01 International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study Gray, Charmaine S Xu, Yao Babl, Franz E Dalziel, Stuart Powell, Colin V E Chong, Shu-Ling Roland, Damian Lyttle, Mark D Fernandes, Ricardo M Benito, Javier Johnson, Mike Yock-Corrales, Adriana Santhanam, Indumathy Schuh, Suzanne Cheema, Baljit Couper, Jenny Craig, Simon BMJ Open Respir Res Asthma BACKGROUND: Acute exacerbations of asthma are common in children, however, treatment decisions for severe exacerbations are challenging due to a lack of robust evidence. In order to create more robust research, a core set of outcome measures needs to be developed. In developing these outcomes, it is important to understand the views of clinicians who care for these children in particular, views that relate to outcome measures and research priorities. METHODS: To determine the views of clinicians, a total of 26 semistructured interviews based on the theoretical domains framework were conducted. These included experienced clinicians from emergency, intensive care and inpatient paediatrics across 17 countries. The interviews were recorded, and later transcribed. All data analyses were conducted in Nvivo by using thematic analysis. RESULTS: The length of stay in hospital and patient-focused parameters, such as timing to return to school and normal activity, were the most frequently highlighted outcome measures, with clinicians identifying the need to achieve a consensus on key core outcome measure sets. Most research questions focused on understanding the best treatment options, including the role of novel therapies and respiratory support. CONCLUSION: Our study provides an insight into what research questions and outcome measures clinicians view as important. In addition, information on how clinicians define asthma severity and measure treatment success will assist with methodological design in future trials. The current findings will be used in parallel with a further Paediatric Emergency Research Network study focusing on the child and family perspectives and will contribute to develop a core outcome set for future research. BMJ Publishing Group 2023-02-27 /pmc/articles/PMC9972434/ /pubmed/36849194 http://dx.doi.org/10.1136/bmjresp-2022-001502 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Asthma
Gray, Charmaine S
Xu, Yao
Babl, Franz E
Dalziel, Stuart
Powell, Colin V E
Chong, Shu-Ling
Roland, Damian
Lyttle, Mark D
Fernandes, Ricardo M
Benito, Javier
Johnson, Mike
Yock-Corrales, Adriana
Santhanam, Indumathy
Schuh, Suzanne
Cheema, Baljit
Couper, Jenny
Craig, Simon
International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study
title International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study
title_full International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study
title_fullStr International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study
title_full_unstemmed International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study
title_short International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study
title_sort international perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study
topic Asthma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972434/
https://www.ncbi.nlm.nih.gov/pubmed/36849194
http://dx.doi.org/10.1136/bmjresp-2022-001502
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