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Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6

BACKGROUND: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) contribute to an impaired functionality of natural killer (NK) cells that have emerged as a promising therapeutic modality. The interaction between CAFs and NK cells within the TME exerts major inhibitory effects on...

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Detalles Bibliográficos
Autores principales:	Lee, Young Eun, Go, Ga-Yeon, Koh, Eun-Young, Yoon, Han-Na, Seo, Minkoo, Hong, Seung-Mo, Jeong, Ji Hye, Kim, Jin-Chul, Cho, Duck, Kim, Tae Sung, Kim, Song Cheol, Jun, Eunsung, Jang, Mihue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972461/ https://www.ncbi.nlm.nih.gov/pubmed/36849201 http://dx.doi.org/10.1136/jitc-2022-006130

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