Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial

BACKGROUND: People who experience an ischaemic stroke are at risk of recurrent vascular events, progression of cerebrovascular disease, and cognitive decline. We assessed whether allopurinol, a xanthine oxidase inhibitor, reduced white matter hyperintensity (WMH) progression and blood pressure (BP)...

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Autores principales: Dawson, Jesse, Robertson, Michele, Dickie, David Alexander, Bath, Phillip, Forbes, Kirsten, Quinn, Terence, Broomfield, Niall M., Dani, Krishna, Doney, Alex, Houston, Graeme, Lees, Kennedy R., Muir, Keith W., Struthers, Allan, Walters, Matthew, Barber, Mark, Bhalla, Ajay, Cameron, Alan, Dyker, Alexander, Guyler, Paul, Hassan, Ahamad, Kearney, Mark T., Keegan, Breffni, Lakshmanan, Sekaran, Macleod, Mary Joan, Randall, Marc, Shaw, Louise, Subramanian, Ganesh, Werring, David, McConnachie, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972492/
https://www.ncbi.nlm.nih.gov/pubmed/36864979
http://dx.doi.org/10.1016/j.eclinm.2023.101863

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