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Heterogeneity in disease resistance and the impact of antibiotics in the US
We hypothesize that the impact of antibiotics is moderated by a population’s inherent (genetic) resistance to infectious disease. Using the introduction of sulfa drugs in 1937, we show that US states that are more genetically susceptible to infectious disease saw larger declines in their bacterial m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972546/ https://www.ncbi.nlm.nih.gov/pubmed/35944452 http://dx.doi.org/10.1016/j.ehb.2022.101155 |
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author | Cook, C. Justin Fletcher, Jason M. |
author_facet | Cook, C. Justin Fletcher, Jason M. |
author_sort | Cook, C. Justin |
collection | PubMed |
description | We hypothesize that the impact of antibiotics is moderated by a population’s inherent (genetic) resistance to infectious disease. Using the introduction of sulfa drugs in 1937, we show that US states that are more genetically susceptible to infectious disease saw larger declines in their bacterial mortality rates following the introduction of sulfa drugs in 1937. This suggests area-level genetic endowments of disease resistance and the discovery of medical technologies have acted as substitutes in determining levels of health across the US. We also document immediate effects of sulfa drug exposure to the age of the workforce and cumulative effects on educational attainment for cohorts exposed to sulfa drugs in early life. |
format | Online Article Text |
id | pubmed-9972546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-99725462023-02-28 Heterogeneity in disease resistance and the impact of antibiotics in the US Cook, C. Justin Fletcher, Jason M. Econ Hum Biol Article We hypothesize that the impact of antibiotics is moderated by a population’s inherent (genetic) resistance to infectious disease. Using the introduction of sulfa drugs in 1937, we show that US states that are more genetically susceptible to infectious disease saw larger declines in their bacterial mortality rates following the introduction of sulfa drugs in 1937. This suggests area-level genetic endowments of disease resistance and the discovery of medical technologies have acted as substitutes in determining levels of health across the US. We also document immediate effects of sulfa drug exposure to the age of the workforce and cumulative effects on educational attainment for cohorts exposed to sulfa drugs in early life. 2022-12 2022-07-27 /pmc/articles/PMC9972546/ /pubmed/35944452 http://dx.doi.org/10.1016/j.ehb.2022.101155 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Cook, C. Justin Fletcher, Jason M. Heterogeneity in disease resistance and the impact of antibiotics in the US |
title | Heterogeneity in disease resistance and the impact of antibiotics in the US |
title_full | Heterogeneity in disease resistance and the impact of antibiotics in the US |
title_fullStr | Heterogeneity in disease resistance and the impact of antibiotics in the US |
title_full_unstemmed | Heterogeneity in disease resistance and the impact of antibiotics in the US |
title_short | Heterogeneity in disease resistance and the impact of antibiotics in the US |
title_sort | heterogeneity in disease resistance and the impact of antibiotics in the us |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972546/ https://www.ncbi.nlm.nih.gov/pubmed/35944452 http://dx.doi.org/10.1016/j.ehb.2022.101155 |
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