Oxidative stress and epigenetics in ocular vascular aging: an updated review

Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular diseases. Diabetic retinopathy (DR) and age-related macular degeneration (AMD), characterized by microvascular dysfunction, are the common causes of irrevers...

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Autores principales: Zhao, Bowen, Zhu, Lijia, Ye, Meng, Lou, Xiaotong, Mou, Qianxue, Hu, Yuanyuan, Zhang, Hong, Zhao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972630/
https://www.ncbi.nlm.nih.gov/pubmed/36849907
http://dx.doi.org/10.1186/s10020-023-00624-7
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author Zhao, Bowen
Zhu, Lijia
Ye, Meng
Lou, Xiaotong
Mou, Qianxue
Hu, Yuanyuan
Zhang, Hong
Zhao, Yin
author_facet Zhao, Bowen
Zhu, Lijia
Ye, Meng
Lou, Xiaotong
Mou, Qianxue
Hu, Yuanyuan
Zhang, Hong
Zhao, Yin
author_sort Zhao, Bowen
collection PubMed
description Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular diseases. Diabetic retinopathy (DR) and age-related macular degeneration (AMD), characterized by microvascular dysfunction, are the common causes of irreversible blindness worldwide, however there is still a lack of effective therapeutic strategies for rescuing the visual function. In order to develop novel treatments, it is essential to illuminate the pathological mechanisms underlying the vascular aging during DR and AMD progression. In this review, we have summarized the recent discoveries of the effects of oxidative stress and epigenetics on microvascular degeneration, which could provide potential therapeutic targets for DR and AMD.
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spelling pubmed-99726302023-03-01 Oxidative stress and epigenetics in ocular vascular aging: an updated review Zhao, Bowen Zhu, Lijia Ye, Meng Lou, Xiaotong Mou, Qianxue Hu, Yuanyuan Zhang, Hong Zhao, Yin Mol Med Review Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular diseases. Diabetic retinopathy (DR) and age-related macular degeneration (AMD), characterized by microvascular dysfunction, are the common causes of irreversible blindness worldwide, however there is still a lack of effective therapeutic strategies for rescuing the visual function. In order to develop novel treatments, it is essential to illuminate the pathological mechanisms underlying the vascular aging during DR and AMD progression. In this review, we have summarized the recent discoveries of the effects of oxidative stress and epigenetics on microvascular degeneration, which could provide potential therapeutic targets for DR and AMD. BioMed Central 2023-02-27 /pmc/articles/PMC9972630/ /pubmed/36849907 http://dx.doi.org/10.1186/s10020-023-00624-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Zhao, Bowen
Zhu, Lijia
Ye, Meng
Lou, Xiaotong
Mou, Qianxue
Hu, Yuanyuan
Zhang, Hong
Zhao, Yin
Oxidative stress and epigenetics in ocular vascular aging: an updated review
title Oxidative stress and epigenetics in ocular vascular aging: an updated review
title_full Oxidative stress and epigenetics in ocular vascular aging: an updated review
title_fullStr Oxidative stress and epigenetics in ocular vascular aging: an updated review
title_full_unstemmed Oxidative stress and epigenetics in ocular vascular aging: an updated review
title_short Oxidative stress and epigenetics in ocular vascular aging: an updated review
title_sort oxidative stress and epigenetics in ocular vascular aging: an updated review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972630/
https://www.ncbi.nlm.nih.gov/pubmed/36849907
http://dx.doi.org/10.1186/s10020-023-00624-7
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