Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications

BACKGROUND: Glioblastoma (GBM, WHO grade IV) is an aggressive, primary brain tumor. Despite extensive tumor resection followed by radio- and chemotherapy, life expectancy of GBM patients did not improve over decades. Several studies reported transcription deregulation in GBMs, but regulatory mechani...

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Detalles Bibliográficos
Autores principales: Roura, Adria-Jaume, Szadkowska, Paulina, Poleszak, Katarzyna, Dabrowski, Michal J., Ellert-Miklaszewska, Aleksandra, Wojnicki, Kamil, Ciechomska, Iwona A., Stepniak, Karolina, Kaminska, Bozena, Wojtas, Bartosz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972689/
https://www.ncbi.nlm.nih.gov/pubmed/36850002
http://dx.doi.org/10.1186/s13148-023-01446-4

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