correctKin: an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes

Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulatio...

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Detalles Bibliográficos
Autores principales: Nyerki, Emil, Kalmár, Tibor, Schütz, Oszkár, Lima, Rui M., Neparáczki, Endre, Török, Tibor, Maróti, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972692/
https://www.ncbi.nlm.nih.gov/pubmed/36855115
http://dx.doi.org/10.1186/s13059-023-02882-4
Descripción
Sumario:Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulations and also validate correctKin on experimental modern and ancient data with widely different genome coverages (0.12×–11.9×) using samples with known family relations and known/unknown population structure. Based on our results, correctKin allows for the reliable identification of relatedness up to the 4th degree from variable/low-coverage ancient or badly degraded forensic whole genome sequencing data. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-023-02882-4.

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