A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis

BACKGROUND: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses. CASE PRESENTATION: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperh...

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Autores principales: Aftahy, A. Kaywan, Butenschoen, Vicki M., Hoenikl, Lisa, Liesche-Starnecker, Friederike, Wiestler, Benedikt, Schmidt-Graf, Friederike, Meyer, Bernhard, Gempt, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972747/
https://www.ncbi.nlm.nih.gov/pubmed/36855102
http://dx.doi.org/10.1186/s12883-023-03135-4
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author Aftahy, A. Kaywan
Butenschoen, Vicki M.
Hoenikl, Lisa
Liesche-Starnecker, Friederike
Wiestler, Benedikt
Schmidt-Graf, Friederike
Meyer, Bernhard
Gempt, Jens
author_facet Aftahy, A. Kaywan
Butenschoen, Vicki M.
Hoenikl, Lisa
Liesche-Starnecker, Friederike
Wiestler, Benedikt
Schmidt-Graf, Friederike
Meyer, Bernhard
Gempt, Jens
author_sort Aftahy, A. Kaywan
collection PubMed
description BACKGROUND: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses. CASE PRESENTATION: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating. CONCLUSIONS: H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis.
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spelling pubmed-99727472023-03-01 A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis Aftahy, A. Kaywan Butenschoen, Vicki M. Hoenikl, Lisa Liesche-Starnecker, Friederike Wiestler, Benedikt Schmidt-Graf, Friederike Meyer, Bernhard Gempt, Jens BMC Neurol Case Report BACKGROUND: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses. CASE PRESENTATION: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating. CONCLUSIONS: H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis. BioMed Central 2023-02-28 /pmc/articles/PMC9972747/ /pubmed/36855102 http://dx.doi.org/10.1186/s12883-023-03135-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Aftahy, A. Kaywan
Butenschoen, Vicki M.
Hoenikl, Lisa
Liesche-Starnecker, Friederike
Wiestler, Benedikt
Schmidt-Graf, Friederike
Meyer, Bernhard
Gempt, Jens
A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis
title A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis
title_full A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis
title_fullStr A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis
title_full_unstemmed A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis
title_short A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis
title_sort rare case of h3k27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972747/
https://www.ncbi.nlm.nih.gov/pubmed/36855102
http://dx.doi.org/10.1186/s12883-023-03135-4
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