Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)

An iron(III) chloride hexahydrate-catalyzed Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates d...

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Detalles Bibliográficos
Autores principales: Lerch, Swantje, Fritsch, Stefan, Strassner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972882/
https://www.ncbi.nlm.nih.gov/pubmed/36865025
http://dx.doi.org/10.3762/bjoc.19.20
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author Lerch, Swantje
Fritsch, Stefan
Strassner, Thomas
author_facet Lerch, Swantje
Fritsch, Stefan
Strassner, Thomas
author_sort Lerch, Swantje
collection PubMed
description An iron(III) chloride hexahydrate-catalyzed Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale.
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spelling pubmed-99728822023-03-01 Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) Lerch, Swantje Fritsch, Stefan Strassner, Thomas Beilstein J Org Chem Full Research Paper An iron(III) chloride hexahydrate-catalyzed Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale. Beilstein-Institut 2023-02-23 /pmc/articles/PMC9972882/ /pubmed/36865025 http://dx.doi.org/10.3762/bjoc.19.20 Text en Copyright © 2023, Lerch et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Lerch, Swantje
Fritsch, Stefan
Strassner, Thomas
Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)
title Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)
title_full Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)
title_fullStr Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)
title_full_unstemmed Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)
title_short Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)
title_sort friedel–crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (taails)
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972882/
https://www.ncbi.nlm.nih.gov/pubmed/36865025
http://dx.doi.org/10.3762/bjoc.19.20
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AT strassnerthomas friedelcraftsacylationofbenzenederivativesintunablearylalkylionicliquidstaails

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