Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

The relationship between diabetes and COVID-19 is bi-directional: while individuals with diabetes and high blood glucose (hyperglycemia) are predisposed to severe COVID-19, SARS-CoV-2 infection can also cause hyperglycemia and exacerbate underlying metabolic syndrome. Therefore, interventions capabl...

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Detalles Bibliográficos
Autores principales: Zhu, Bibo, Wei, Xiaoqin, Narasimhan, Harish, Qian, Wei, Zhang, Ruixuan, Cheon, In Su, Wu, Yue, Li, Chaofan, Jones, Russell G., Kaplan, Mark H., Vassallo, Robert A., Braciale, Thomas J., Somerville, Lindsay, Colca, Jerry R., Pandey, Akhilesh, Jackson, Patrick E. H., Mann, Barbara J., Krawczyk, Connie M., Sturek, Jeffrey M., Sun, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972900/
https://www.ncbi.nlm.nih.gov/pubmed/36821695
http://dx.doi.org/10.1126/sciimmunol.adf0348

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