A multiplexed in vivo approach to identify driver genes in small cell lung cancer

Small cell lung cancer (SCLC) is a lethal form of lung cancer. Here, we develop a quantitative multiplexed approach on the basis of lentiviral barcoding with somatic CRISPR-Cas9-mediated genome editing to functionally investigate candidate regulators of tumor initiation and growth in genetically eng...

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Detalles Bibliográficos
Autores principales: Lee, Myung Chang, Cai, Hongchen, Murray, Christopher W., Li, Chuan, Shue, Yan Ting, Andrejka, Laura, He, Andy L., Holzem, Alessandra M.E., Drainas, Alexandros P., Ko, Julie H., Coles, Garry L., Kong, Christina, Zhu, Shirley, Zhu, ChunFang, Wang, Jason, van de Rijn, Matt, Petrov, Dmitri A., Winslow, Monte M., Sage, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972901/
https://www.ncbi.nlm.nih.gov/pubmed/36640300
http://dx.doi.org/10.1016/j.celrep.2023.111990

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