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Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial

OBJECTIVES: In this double-blind, randomized clinical trial, the effectiveness of buprenorphine (BUPRE) in the reduction of anxiety symptoms among the methamphetamine (MA) dependents was evaluated. MATERIALS AND METHODS: The 60 MA-dependent patients were randomly assigned to three groups (0.1 mg, 1...

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Autores principales: Ahmadi, Jamshid, Bazrafshan, Amir, Sahraian, Ali, Jalali, Sara, Fakhermanesh, Maedeh, Hooshyari, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972937/
https://www.ncbi.nlm.nih.gov/pubmed/36866345
http://dx.doi.org/10.4103/tcmj.tcmj_297_21
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author Ahmadi, Jamshid
Bazrafshan, Amir
Sahraian, Ali
Jalali, Sara
Fakhermanesh, Maedeh
Hooshyari, Zahra
author_facet Ahmadi, Jamshid
Bazrafshan, Amir
Sahraian, Ali
Jalali, Sara
Fakhermanesh, Maedeh
Hooshyari, Zahra
author_sort Ahmadi, Jamshid
collection PubMed
description OBJECTIVES: In this double-blind, randomized clinical trial, the effectiveness of buprenorphine (BUPRE) in the reduction of anxiety symptoms among the methamphetamine (MA) dependents was evaluated. MATERIALS AND METHODS: The 60 MA-dependent patients were randomly assigned to three groups (0.1 mg, 1 mg, and 8 mg of BUPRE), The Hamilton Anxiety Rating Scale was administrated to assess the anxiety symptoms daily at baseline and second to the 5(th) day after intervention. The inclusion criteria were the MA dependence, age of over 18 years, and absence of any chronic physical illnesses; exclusion criteria were the presence of other drug dependence in combination with MA. The mixed-design analysis of variance was performed for data analysis. RESULTS: A significant main effect of time (F = 51.456, P < 0.001) and group (F = 4.572, P = 0.014) and group-by-time interaction (F = 8.475, P < 0.001) were detected. CONCLUSIONS: This finding supports the efficacy of BUPRE to decrease anxiety. High doses of the drug (1 and 8 mg) were more effective than 0.1 mg. Here was not a significant difference between anxiety score when patients received 1 mg of BUPRE instead of 8 mg.
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spelling pubmed-99729372023-03-01 Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial Ahmadi, Jamshid Bazrafshan, Amir Sahraian, Ali Jalali, Sara Fakhermanesh, Maedeh Hooshyari, Zahra Tzu Chi Med J Original Article OBJECTIVES: In this double-blind, randomized clinical trial, the effectiveness of buprenorphine (BUPRE) in the reduction of anxiety symptoms among the methamphetamine (MA) dependents was evaluated. MATERIALS AND METHODS: The 60 MA-dependent patients were randomly assigned to three groups (0.1 mg, 1 mg, and 8 mg of BUPRE), The Hamilton Anxiety Rating Scale was administrated to assess the anxiety symptoms daily at baseline and second to the 5(th) day after intervention. The inclusion criteria were the MA dependence, age of over 18 years, and absence of any chronic physical illnesses; exclusion criteria were the presence of other drug dependence in combination with MA. The mixed-design analysis of variance was performed for data analysis. RESULTS: A significant main effect of time (F = 51.456, P < 0.001) and group (F = 4.572, P = 0.014) and group-by-time interaction (F = 8.475, P < 0.001) were detected. CONCLUSIONS: This finding supports the efficacy of BUPRE to decrease anxiety. High doses of the drug (1 and 8 mg) were more effective than 0.1 mg. Here was not a significant difference between anxiety score when patients received 1 mg of BUPRE instead of 8 mg. Wolters Kluwer - Medknow 2022-06-14 /pmc/articles/PMC9972937/ /pubmed/36866345 http://dx.doi.org/10.4103/tcmj.tcmj_297_21 Text en Copyright: © 2022 Tzu Chi Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Ahmadi, Jamshid
Bazrafshan, Amir
Sahraian, Ali
Jalali, Sara
Fakhermanesh, Maedeh
Hooshyari, Zahra
Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial
title Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial
title_full Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial
title_fullStr Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial
title_full_unstemmed Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial
title_short Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial
title_sort anxiety treatment of methamphetamine-dependent patients with buprenorphine: a randomized, double-blind, clinical trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972937/
https://www.ncbi.nlm.nih.gov/pubmed/36866345
http://dx.doi.org/10.4103/tcmj.tcmj_297_21
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