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Avian Influenza A Virus Polymerase Can Utilize Human ANP32 Proteins To Support cRNA but Not vRNA Synthesis
Host restriction limits the emergence of novel pandemic strains from the influenza A virus avian reservoir. For efficient replication in mammalian cells, the avian influenza RNA-dependent RNA polymerase must adapt to use human orthologues of the host factor ANP32, which lack a 33-amino-acid insertio...
Autores principales: | Swann, Olivia C., Rasmussen, Amalie B., Peacock, Thomas P., Sheppard, Carol M., Barclay, Wendy S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973007/ https://www.ncbi.nlm.nih.gov/pubmed/36645303 http://dx.doi.org/10.1128/mbio.03399-22 |
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