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Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression

Toxoplasma gondii secretes various virulence effector molecules into host cells to disrupt host interferon-γ (IFN-γ)-dependent immunity. Among these effectors, ROP18 directly phosphorylates and inactivates IFN-inducible GTPases, such as immunity-related GTPases (IRGs) and guanylate-binding proteins...

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Detalles Bibliográficos
Autores principales:	Hashizaki, Emi, Sasai, Miwa, Okuzaki, Daisuke, Nishi, Tsubasa, Kobayashi, Takashi, Iwanaga, Shiroh, Yamamoto, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973038/ https://www.ncbi.nlm.nih.gov/pubmed/36715543 http://dx.doi.org/10.1128/mbio.03256-22

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