Therapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease

Phenotypic screening has yielded small-molecule inhibitors of prion replication that are effective in vivo against certain prion strains but not others. Here, we sought to test the small molecule anle138b in multiple mouse models of prion disease. In mice inoculated with the RML strain of prions, an...

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Detalles Bibliográficos
Autores principales: Vallabh, Sonia M., Zou, Dan, Pitstick, Rose, O’Moore, Jill, Peters, Janet, Silvius, Derek, Kriz, Jasna, Jackson, Walker S., Carlson, George A., Minikel, Eric Vallabh, Cabin, Deborah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Prions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973041/
https://www.ncbi.nlm.nih.gov/pubmed/36651748
http://dx.doi.org/10.1128/jvi.01672-22

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