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Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients
INTRODUCTION: The measured D-dimer levels in coronavirus disease-2019 (COVID-19) patients have no specific cutoff to find the progression of coagulopathy and severity. AIM: This study aimed to determine prognostic cutoff values of D-dimer for intensive care unit (ICU) admission among COVID-19 patien...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Jaypee Brothers Medical Publishers
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973051/ https://www.ncbi.nlm.nih.gov/pubmed/36865519 http://dx.doi.org/10.5005/jp-journals-10071-24395 |
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author | Anton, Mary Chandrika Shanthi, B Vasudevan, E |
author_facet | Anton, Mary Chandrika Shanthi, B Vasudevan, E |
author_sort | Anton, Mary Chandrika |
collection | PubMed |
description | INTRODUCTION: The measured D-dimer levels in coronavirus disease-2019 (COVID-19) patients have no specific cutoff to find the progression of coagulopathy and severity. AIM: This study aimed to determine prognostic cutoff values of D-dimer for intensive care unit (ICU) admission among COVID-19 patients. MATERIALS AND METHODS: This cross-sectional study was conducted in Sree Balaji Medical College and Hospital, Chennai, during a period of 6 months. This study included 460 COVID-19-positive individuals. RESULTS: The mean age was 52.2 ± 12.53 years. Patients with mild illness have D-dimer value 461.8 ± 221, whereas moderate and severe COVID illness patients have D-dimer values of 1915.2 ± 699.9 and 7937.6 ± 2045.2, respectively. D-dimer cutoff value of 1036.9 is shown to be a prognostic cutoff value for COVID-19 patients admitted in the ICU with 99% sensitivity and 17% specificity. The area under curve (AUC) was considered excellent (AUC = 0.827, 95% Cl: 0.78–0.86, p-value < 0.0001) indicative of high sensitivity. CONCLUSION: The D-dimer value of 1036.9 ng/mL was found to be the optimum cutoff for the patients to predict the severity of the COVID-19-positive patients admitted in the ICU. HOW TO CITE THIS ARTICLE: Anton MC, Shanthi B, Vasudevan E. Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients. Indian J Crit Care Med 2023;27(2):135–138. |
format | Online Article Text |
id | pubmed-9973051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Jaypee Brothers Medical Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-99730512023-03-01 Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients Anton, Mary Chandrika Shanthi, B Vasudevan, E Indian J Crit Care Med Brief Research Communication INTRODUCTION: The measured D-dimer levels in coronavirus disease-2019 (COVID-19) patients have no specific cutoff to find the progression of coagulopathy and severity. AIM: This study aimed to determine prognostic cutoff values of D-dimer for intensive care unit (ICU) admission among COVID-19 patients. MATERIALS AND METHODS: This cross-sectional study was conducted in Sree Balaji Medical College and Hospital, Chennai, during a period of 6 months. This study included 460 COVID-19-positive individuals. RESULTS: The mean age was 52.2 ± 12.53 years. Patients with mild illness have D-dimer value 461.8 ± 221, whereas moderate and severe COVID illness patients have D-dimer values of 1915.2 ± 699.9 and 7937.6 ± 2045.2, respectively. D-dimer cutoff value of 1036.9 is shown to be a prognostic cutoff value for COVID-19 patients admitted in the ICU with 99% sensitivity and 17% specificity. The area under curve (AUC) was considered excellent (AUC = 0.827, 95% Cl: 0.78–0.86, p-value < 0.0001) indicative of high sensitivity. CONCLUSION: The D-dimer value of 1036.9 ng/mL was found to be the optimum cutoff for the patients to predict the severity of the COVID-19-positive patients admitted in the ICU. HOW TO CITE THIS ARTICLE: Anton MC, Shanthi B, Vasudevan E. Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients. Indian J Crit Care Med 2023;27(2):135–138. Jaypee Brothers Medical Publishers 2023-02 /pmc/articles/PMC9973051/ /pubmed/36865519 http://dx.doi.org/10.5005/jp-journals-10071-24395 Text en Copyright © 2023; The Author(s). https://creativecommons.org/licenses/by-nc/4.0/© The Author(s). 2023 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Brief Research Communication Anton, Mary Chandrika Shanthi, B Vasudevan, E Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients |
title | Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients |
title_full | Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients |
title_fullStr | Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients |
title_full_unstemmed | Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients |
title_short | Study to Determine a Prognostic Cutoff Values of the Coagulation Analyte D-dimer for ICU Admission among COVID-19 Patients |
title_sort | study to determine a prognostic cutoff values of the coagulation analyte d-dimer for icu admission among covid-19 patients |
topic | Brief Research Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973051/ https://www.ncbi.nlm.nih.gov/pubmed/36865519 http://dx.doi.org/10.5005/jp-journals-10071-24395 |
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