Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase

Coronaviruses express a papain-like protease (PLpro) that is required for replicase polyprotein maturation and also serves as a deubiquitinating enzyme (DUB). In this study, using a Middle East respiratory syndrome virus (MERS-CoV) PLpro modified virus in which the DUB is selectively inactivated, we...

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Detalles Bibliográficos
Autores principales: Myeni, Sebenzile K., Bredenbeek, Peter J., Knaap, Robert C. M., Dalebout, Tim J., Morales, Shessy Torres, Sidorov, Igor A., Linger, Marissa E., Oreshkova, Nadia, van Zanen-Gerhardt, Sophie, Zander, Serge A. L., Enjuanes, Luis, Sola, Isabel, Snijder, Eric J., Kikkert, Marjolein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973250/
https://www.ncbi.nlm.nih.gov/pubmed/36854765
http://dx.doi.org/10.1038/s41467-023-36754-z

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