Cargando…

Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis

The global burden of tuberculosis (TB) is aggravated by the continuously increasing emergence of drug resistance, highlighting the need for innovative therapeutic options. The concept of host-directed therapy (HDT) as adjunctive to classical antibacterial therapy with antibiotics represents a novel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boland, Ralf, Heemskerk, Matthias T., Forn-Cuní, Gabriel, Korbee, Cornelis J., Walburg, Kimberley V., Esselink, Jeroen J., Carvalho dos Santos, Carina, de Waal, Amy M., van der Hoeven, Daniel C. M., van der Sar, Elisa, de Ries, Alex S., Xie, Jiajun, Spaink, Herman P., van der Vaart, Michiel, Haks, Mariëlle C., Meijer, Annemarie H., Ottenhoff, Tom H. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973281/ https://www.ncbi.nlm.nih.gov/pubmed/36475748 http://dx.doi.org/10.1128/mbio.03024-22

Ejemplares similares

Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections
por: Heemskerk, M. T., et al.
Publicado: (2021)

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish
por: Moreira, Jôsimar D., et al.
Publicado: (2020)

Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of Salmonella enterica Serovar Typhimurium Infection in Human Macrophages
por: van Doorn, Cassandra L. R., et al.
Publicado: (2021)

Bioorthogonal Correlative Light-Electron Microscopy of Mycobacterium tuberculosis in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution
por: Bakkum, Thomas, et al.
Publicado: (2020)

The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection
por: Zhang, Rui, et al.
Publicado: (2019)

Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages
por: Zhang, Rui, et al.
Publicado: (2020)

Drug Resistance in Nontuberculous Mycobacteria: Mechanisms and Models
por: Saxena, Saloni, et al.
Publicado: (2021)

Development of Human Cell-Based In Vitro Infection Models to Determine the Intracellular Survival of Mycobacterium avium
por: Kilinç, Gül, et al.
Publicado: (2022)

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
por: Korbee, Cornelis J., et al.
Publicado: (2018)

Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways
por: Ding, Yi, et al.
Publicado: (2021)

Recombinant BCG-LTAK63 Vaccine Candidate for Tuberculosis Induces an Inflammatory Profile in Human Macrophages
por: dos Santos, Carina C., et al.
Publicado: (2022)

Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish
por: van der Vaart, Michiel, et al.
Publicado: (2012)

Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics
por: Vrieling, Frank, et al.
Publicado: (2020)

Transcriptomic and Metabolomic Studies Reveal That Toll-like Receptor 2 Has a Role in Glucose-Related Metabolism in Unchallenged Zebrafish Larvae (Danio rerio)
por: Hu, Wanbin, et al.
Publicado: (2023)

Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease Mycobacterium tuberculosis Survival in Human Macrophages
por: van Doorn, Cassandra L. R., et al.
Publicado: (2021)

Specificity of the innate immune responses to different classes of non-tuberculous mycobacteria
por: Hu, Wanbin, et al.
Publicado: (2023)

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system
por: van der Vaart, Michiel, et al.
Publicado: (2013)

Drug repurposing in cardiology
por: van Driel, B. O., et al.
Publicado: (2020)

Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects
por: van der Lans, Anouk A J J, et al.
Publicado: (2015)

Host‐directed therapy to combat mycobacterial infections
por: Kilinç, Gül, et al.
Publicado: (2021)

Medical educators’ beliefs about teaching, learning, and knowledge: development of a new framework
por: Ottenhoff- de Jonge, Marleen W., et al.
Publicado: (2021)

Biomarkers Can Identify Pulmonary Tuberculosis in HIV-infected Drug Users Months Prior to Clinical Diagnosis
por: Sloot, Rosa, et al.
Publicado: (2014)

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection
por: Torraca, Vincenzo, et al.
Publicado: (2015)

Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome
por: Ding, Yi, et al.
Publicado: (2022)

Human CD8(+) T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell Subset
por: van Meijgaarden, Krista E., et al.
Publicado: (2015)

Best prediction for need of dialysis following cardiac surgery is obtained with the Thakar model
por: Kiers, HD, et al.
Publicado: (2011)

GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish
por: Marín-Juez, Rubén, et al.
Publicado: (2015)

Outcome in patients with idiopathic retroperitoneal fibrosis treated with corticosteroid or tamoxifen monotherapy
por: van der Bilt, Floor E., et al.
Publicado: (2016)

Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development
por: Van Wijk, Rob C., et al.
Publicado: (2020)

Predicting the development of stress urinary incontinence 3 years after hysterectomy
por: Lakeman, Mariëlle M. E., et al.
Publicado: (2011)

Inflammation-induced renal injury subsides when endotoxin tolerance develops in humans as measured by urine proteomics
por: Draisma, A, et al.
Publicado: (2009)

New markers of inflammation-induced renal injury subside when endotoxin tolerance develops in humans as measured by urine proteomics
por: Heemskerk, S, et al.
Publicado: (2010)

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
por: Benard, Erica L., et al.
Publicado: (2012)

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
por: Soldati, Chiara, et al.
Publicado: (2021)

Genome Sequence of Aeromonas hydrophila Strain AH-3 (Serotype O34)
por: Forn-Cuní, Gabriel, et al.
Publicado: (2016)

Whole-Genome Sequence of Aeromonas hydrophila Strain AH-1 (Serotype O11)
por: Forn-Cuní, Gabriel, et al.
Publicado: (2016)

Comparative Genomics of the Aeromonadaceae Core Oligosaccharide Biosynthetic Regions
por: Forn-Cuní, Gabriel, et al.
Publicado: (2017)

Upregulation of renal inducible NO synthase and proximal tubule damage during human endotoxemia
por: Heemskerk, S, et al.
Publicado: (2004)

Mycobacteria Counteract a TLR-Mediated Nitrosative Defense Mechanism in a Zebrafish Infection Model
por: Elks, Philip M., et al.
Publicado: (2014)

Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis
por: de Waal, Amy M, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n68h88oa78tgj3cfd7vl6qrup0