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A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy to avoid FLC resistance and eliminate the per...

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Detalles Bibliográficos
Autores principales:	Lu, Hui, Li, Wanqian, Whiteway, Malcolm, Wang, Hongkang, Zhu, Shuo, Ji, Zhe, Feng, Yanru, Yan, Lan, Fang, Ting, Li, Liping, Ni, Tingjunhong, Zhang, Xiaolong, Lv, Quanzhen, Ding, Zichao, Qiu, Lijuan, Zhang, Dazhi, Jiang, Yuanying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973333/ https://www.ncbi.nlm.nih.gov/pubmed/36475771 http://dx.doi.org/10.1128/mbio.02639-22

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