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Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity

The Escherichia coli acriflavine resistance protein D (AcrD) is an efflux pump that belongs to the resistance-nodulation-cell division (RND) superfamily. Its primary function is to provide resistance to aminoglycoside-based drugs by actively extruding these noxious compounds out of E. coli cells. Ac...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhemin, Morgan, Christopher E., Cui, Meng, Yu, Edward W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973356/ https://www.ncbi.nlm.nih.gov/pubmed/36625574 http://dx.doi.org/10.1128/mbio.03383-22

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