Chimeric Antigen Receptors Directed at Mutant KRAS Exhibit an Inverse Relationship Between Functional Potency and Neoantigen Selectivity

Neoantigens are among the most intriguing potential immuno-oncology targets because, unlike many cancer targets that are expressed on normal tissues, they are by definition restricted to cancer cells. Medicines directed at common neoantigens such as mutant KRAS are especially interesting because the...

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Detalles Bibliográficos
Autores principales: Tokatlian, Talar, Asuelime, Grace E., Naradikian, Martin S., Mock, Jee-Young, Daris, Mark E., Martin, Aaron D., Toledo Warshaviak, Dora, Kamb, Alexander, Hamburger, Agnes E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973398/
https://www.ncbi.nlm.nih.gov/pubmed/36860694
http://dx.doi.org/10.1158/2767-9764.CRC-21-0165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973398/
https://www.ncbi.nlm.nih.gov/pubmed/36860694
http://dx.doi.org/10.1158/2767-9764.CRC-21-0165

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