BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to PARP Inhibitors and Cisplatin

Homologous recombination (HR)-deficient cells are sensitive to PARP inhibitors through a synthetic lethal effect. We previously developed an HR activity assay named Assay of Site-Specific HR Activity (ASHRA). Here, we evaluated the HR activity of 30 missense variants of BRCA1 by ASHRA and found that...

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Detalles Bibliográficos
Autores principales: Endo, Shino, Yoshino, Yuki, Shirota, Matsuyuki, Watanabe, Gou, Chiba, Natsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973406/
https://www.ncbi.nlm.nih.gov/pubmed/36860287
http://dx.doi.org/10.1158/2767-9764.CRC-21-0064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973406/
https://www.ncbi.nlm.nih.gov/pubmed/36860287
http://dx.doi.org/10.1158/2767-9764.CRC-21-0064

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