An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations

Despite the relatively high frequency of somatic ERBB4 mutations in various cancer types, only a few activating ERBB4 mutations have been characterized, primarily due to lack of mutational hotspots in the ERBB4 gene. Here, we utilized our previously published pipeline, an in vitro screen for activat...

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Detalles Bibliográficos
Autores principales: Chakroborty, Deepankar, Ojala, Veera K., Knittle, Anna M., Drexler, Jasmin, Tamirat, Mahlet Z., Ruzicka, Regina, Bosch, Karin, Woertl, Johanna, Schmittner, Susanne, Elo, Laura L., Johnson, Mark S., Kurppa, Kari J., Solca, Flavio, Elenius, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973412/
https://www.ncbi.nlm.nih.gov/pubmed/36860695
http://dx.doi.org/10.1158/2767-9764.CRC-21-0021

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