Combined Treatment with a WNT Inhibitor and the NSAID Sulindac Reduces Colon Adenoma Burden in Mice with Truncated APC

Adenomatous polyposis coli (APC) truncations occur in many colorectal cancers and are often associated with immune infiltration. The aim of this study was to determine whether a combination of Wnt inhibition with anti-inflammatory (sulindac) and/or proapototic (ABT263) drugs can reduce colon adenoma...

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Detalles Bibliográficos
Autores principales: Faux, Maree C., Weinstock, Janet, Gogos, Sophia, Prato, Emma, Azimpour, Alexander I., O'Keefe, Ryan, Cathcart-King, Yasmin, Garnham, Alexandra L., Ernst, Matthias, Preaudet, Adele, Christie, Michael, Putoczki, Tracy L., Buchert, Michael, Burgess, Antony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973414/
https://www.ncbi.nlm.nih.gov/pubmed/36860494
http://dx.doi.org/10.1158/2767-9764.CRC-21-0105

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