Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms

Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase subtilisin/kexin 9) increases low-density lipoprotein (LDL)-cholesterol levels via LDL receptor (LDLR) degradation....

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Detalles Bibliográficos
Autores principales: Katsuki, Shunsuke, K. Jha, Prabhash, Lupieri, Adrien, Nakano, Toshiaki, Passos, Livia S.A., Rogers, Maximillian A., Becker-Greene, Dakota, Le, Thanh-Dat, Decano, Julius L., Ho Lee, Lang, Guimaraes, Gabriel C., Abdelhamid, Ilyes, Halu, Arda, Muscoloni, Alessandro, V. Cannistraci, Carlo, Higashi, Hideyuki, Zhang, Hengmin, Vromman, Amélie, Libby, Peter, Keith Ozaki, C., Sharma, Amitabh, Singh, Sasha A., Aikawa, Elena, Aikawa, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973449/
https://www.ncbi.nlm.nih.gov/pubmed/36263780
http://dx.doi.org/10.1161/CIRCRESAHA.121.320056

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