Cargando…
A 3D cell culture system for bioengineering human neuromuscular junctions to model ALS
The signals that coordinate and control movement in vertebrates are transmitted from motoneurons (MNs) to their target muscle cells at neuromuscular junctions (NMJs). Human NMJs display unique structural and physiological features, which make them vulnerable to pathological processes. NMJs are an ea...
Autores principales: | Massih, Bita, Veh, Alexander, Schenke, Maren, Mungwa, Simon, Seeger, Bettina, Selvaraj, Bhuvaneish T., Chandran, Siddharthan, Reinhardt, Peter, Sterneckert, Jared, Hermann, Andreas, Sendtner, Michael, Lüningschrör, Patrick |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973451/ https://www.ncbi.nlm.nih.gov/pubmed/36866276 http://dx.doi.org/10.3389/fcell.2023.996952 |
Ejemplares similares
-
Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells
por: Selvaraj, Bhuvaneish T., et al.
Publicado: (2017) -
Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions
por: Rimington, Rowan P., et al.
Publicado: (2021) -
Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves
por: Lüningschrör, Patrick, et al.
Publicado: (2020) -
Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming
por: Rzechorzek, Nina Marie, et al.
Publicado: (2015) -
Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis:
Proposed mechanisms and clinical implications
por: Steinruecke, Moritz, et al.
Publicado: (2023)