STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL and BCLXL following glucocorticoid treatment

Physiological and pathogenic interleukin-7-receptor (IL7R)-induced signaling provokes glucocorticoid resistance in a subset of patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL). Activation of downstream STAT5 has been suggested to cause steroid resistance through upregulation of an...

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Detalles Bibliográficos
Autores principales: van der Zwet, Jordy C.G., Cordo’, Valentina, Buijs-Gladdines, Jessica G.C.A.M., Hagelaar, Rico, Smits, Willem K., Vroegindeweij, Eric, Graus, Laura T.M., Poort, Vera M., Nulle, Marloes, Pieters, Rob, Meijerink, Jules P.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Lymphoblastic Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973477/
https://www.ncbi.nlm.nih.gov/pubmed/35734930
http://dx.doi.org/10.3324/haematol.2021.280405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973477/
https://www.ncbi.nlm.nih.gov/pubmed/35734930
http://dx.doi.org/10.3324/haematol.2021.280405

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