New Cerebral Microbleeds After Catheter‐Based Structural Heart Interventions: An Exploratory Analysis

BACKGROUND: Cerebral microbleeds (CMBs) are increasingly recognized as “covert” brain lesions indicating increased risk of future neurological events. However, data on CMBs in patients undergoing catheter‐based structural heart interventions are scarce. Therefore, we assessed occurrence and predicto...

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Detalles Bibliográficos
Autores principales: Braemswig, Tim Bastian, Kusserow, Madeleine, Bellmann, Barbara, Beckhoff, Frederik, Reinthaler, Markus, von Rennenberg, Regina, Erdur, Hebun, Scheitz, Jan F., Galinovic, Ivana, Villringer, Kersten, Leistner, David M., Audebert, Heinrich J., Endres, Matthias, Landmesser, Ulf, Haeusler, Karl Georg, Fiebach, Jochen B., Lauten, Alexander, Rillig, Andreas, Nolte, Christian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973666/
https://www.ncbi.nlm.nih.gov/pubmed/36734351
http://dx.doi.org/10.1161/JAHA.122.027284
Descripción
Sumario:BACKGROUND: Cerebral microbleeds (CMBs) are increasingly recognized as “covert” brain lesions indicating increased risk of future neurological events. However, data on CMBs in patients undergoing catheter‐based structural heart interventions are scarce. Therefore, we assessed occurrence and predictors of new CMBs in patients undergoing catheter‐based left atrial appendage closure and percutaneous mitral valve repair using the MitraClip System. METHODS AND RESULTS: We conducted an exploratory analysis using data derived from 2 prospective, observational studies. Eligible patients underwent cerebral magnetic resonance imaging (3 Tesla) examinations and cognitive tests (using the Montreal Cognitive Assessment) before and after catheter‐based left atrial appendage closure and percutaneous mitral valve repair. Forty‐seven patients (53% men; median age, 77 years) were included. New CMBs occurred in 17 of 47 patients (36%) following catheter‐based structural heart interventions. Occurrences of new CMBs did not differ significantly between patients undergoing catheter‐based left atrial appendage closure and percutaneous mitral valve repair (7/25 versus 10/22; P=0.348). In univariable analysis, longer procedure time was significantly associated with new CMBs. Adjustment for heparin attenuated this association (adjusted odds ratio [per 30 minutes]: 1.77 [95% CI, 0.92–3.83]; P=0.090). CONCLUSIONS: New CMBs occur in approximately one‐third of patients after catheter‐based left atrial appendage closure and percutaneous mitral valve repair using the MitraClip System. Our data suggest that longer duration of the procedure may be a risk factor for new CMBs. Future studies in larger populations are needed to further investigate their clinical relevance. CLINICAL TRIAL REGISTRATION: German Clinical Trials Register: DRKS00010300 (https://drks.de/search/en/trial/DRKS00010300); ClinicalTrials.gov : NCT03104556 (https://clinicaltrials.gov/ct2/show/NCT03104556?term=NCT03104556&draw=2&rank=1).

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