Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects

Cancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. Serial trypsinization of glioblastoma specimens yielded cells with CAF morphology and single-cell transcriptomic profiles based on their lack of copy number variations (CNVs) and elevated i...

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Detalles Bibliográficos
Autores principales: Jain, Saket, Rick, Jonathan W., Joshi, Rushikesh S., Beniwal, Angad, Spatz, Jordan, Gill, Sabraj, Chang, Alexander Chih-Chieh, Choudhary, Nikita, Nguyen, Alan T., Sudhir, Sweta, Chalif, Eric J., Chen, Jia-Shu, Chandra, Ankush, Haddad, Alexander F., Wadhwa, Harsh, Shah, Sumedh S., Choi, Serah, Hayes, Josie L., Wang, Lin, Yagnik, Garima, Costello, Joseph F., Diaz, Aaron, Heiland, Dieter Henrik, Aghi, Manish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974099/
https://www.ncbi.nlm.nih.gov/pubmed/36856115
http://dx.doi.org/10.1172/JCI147087

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