CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer

Emerging evidence suggests that cryptic translation within long noncoding RNAs (lncRNAs) may produce novel proteins with important developmental/physiological functions. However, the role of this cryptic translation in complex diseases (e.g., cancer) remains elusive. Here, we applied an integrative...

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Detalles Bibliográficos
Autores principales: Zheng, Caishang, Wei, Yanjun, Zhang, Peng, Xu, Longyong, Zhang, Zhenzhen, Lin, Kangyu, Hou, Jiakai, Lv, Xiangdong, Ding, Yao, Chiu, Yulun, Jain, Antrix, Islam, Nelufa, Malovannaya, Anna, Wu, Yun, Ding, Feng, Xu, Han, Sun, Ming, Chen, Xi, Chen, Yiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974104/
https://www.ncbi.nlm.nih.gov/pubmed/36856111
http://dx.doi.org/10.1172/JCI159940

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