Cargando…

Multicenter automatic detection of invasive carcinoma on breast whole slide images

Breast cancer is one of the most prevalent cancers worldwide and pathologists are closely involved in establishing a diagnosis. Tools to assist in making a diagnosis are required to manage the increasing workload. In this context, artificial intelligence (AI) and deep-learning based tools may be use...

Descripción completa

Detalles Bibliográficos
Autores principales: Peyret, Rémy, Pozin, Nicolas, Sockeel, Stéphane, Kammerer-Jacquet, Solène-Florence, Adam, Julien, Bocciarelli, Claire, Ditchi, Yoan, Bontoux, Christophe, Depoilly, Thomas, Guichard, Loris, Lanteri, Elisabeth, Sockeel, Marie, Prévot, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974110/
https://www.ncbi.nlm.nih.gov/pubmed/36854026
http://dx.doi.org/10.1371/journal.pdig.0000091
_version_ 1784898666339762176
author Peyret, Rémy
Pozin, Nicolas
Sockeel, Stéphane
Kammerer-Jacquet, Solène-Florence
Adam, Julien
Bocciarelli, Claire
Ditchi, Yoan
Bontoux, Christophe
Depoilly, Thomas
Guichard, Loris
Lanteri, Elisabeth
Sockeel, Marie
Prévot, Sophie
author_facet Peyret, Rémy
Pozin, Nicolas
Sockeel, Stéphane
Kammerer-Jacquet, Solène-Florence
Adam, Julien
Bocciarelli, Claire
Ditchi, Yoan
Bontoux, Christophe
Depoilly, Thomas
Guichard, Loris
Lanteri, Elisabeth
Sockeel, Marie
Prévot, Sophie
author_sort Peyret, Rémy
collection PubMed
description Breast cancer is one of the most prevalent cancers worldwide and pathologists are closely involved in establishing a diagnosis. Tools to assist in making a diagnosis are required to manage the increasing workload. In this context, artificial intelligence (AI) and deep-learning based tools may be used in daily pathology practice. However, it is challenging to develop fast and reliable algorithms that can be trusted by practitioners, whatever the medical center. We describe a patch-based algorithm that incorporates a convolutional neural network to detect and locate invasive carcinoma on breast whole-slide images. The network was trained on a dataset extracted from a reference acquisition center. We then performed a calibration step based on transfer learning to maintain the performance when translating on a new target acquisition center by using a limited amount of additional training data. Performance was evaluated using classical binary measures (accuracy, recall, precision) for both centers (referred to as “test reference dataset” and “test target dataset”) and at two levels: patch and slide level. At patch level, accuracy, recall, and precision of the model on the reference and target test sets were 92.1% and 96.3%, 95% and 87.8%, and 73.9% and 70.6%, respectively. At slide level, accuracy, recall, and precision were 97.6% and 92.0%, 90.9% and 100%, and 100% and 70.8% for test sets 1 and 2, respectively. The high performance of the algorithm at both centers shows that the calibration process is efficient. This is performed using limited training data from the new target acquisition center and requires that the model is trained beforehand on a large database from a reference center. This methodology allows the implementation of AI diagnostic tools to help in routine pathology practice.
format Online
Article
Text
id pubmed-9974110
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-99741102023-03-01 Multicenter automatic detection of invasive carcinoma on breast whole slide images Peyret, Rémy Pozin, Nicolas Sockeel, Stéphane Kammerer-Jacquet, Solène-Florence Adam, Julien Bocciarelli, Claire Ditchi, Yoan Bontoux, Christophe Depoilly, Thomas Guichard, Loris Lanteri, Elisabeth Sockeel, Marie Prévot, Sophie PLOS Digit Health Research Article Breast cancer is one of the most prevalent cancers worldwide and pathologists are closely involved in establishing a diagnosis. Tools to assist in making a diagnosis are required to manage the increasing workload. In this context, artificial intelligence (AI) and deep-learning based tools may be used in daily pathology practice. However, it is challenging to develop fast and reliable algorithms that can be trusted by practitioners, whatever the medical center. We describe a patch-based algorithm that incorporates a convolutional neural network to detect and locate invasive carcinoma on breast whole-slide images. The network was trained on a dataset extracted from a reference acquisition center. We then performed a calibration step based on transfer learning to maintain the performance when translating on a new target acquisition center by using a limited amount of additional training data. Performance was evaluated using classical binary measures (accuracy, recall, precision) for both centers (referred to as “test reference dataset” and “test target dataset”) and at two levels: patch and slide level. At patch level, accuracy, recall, and precision of the model on the reference and target test sets were 92.1% and 96.3%, 95% and 87.8%, and 73.9% and 70.6%, respectively. At slide level, accuracy, recall, and precision were 97.6% and 92.0%, 90.9% and 100%, and 100% and 70.8% for test sets 1 and 2, respectively. The high performance of the algorithm at both centers shows that the calibration process is efficient. This is performed using limited training data from the new target acquisition center and requires that the model is trained beforehand on a large database from a reference center. This methodology allows the implementation of AI diagnostic tools to help in routine pathology practice. Public Library of Science 2023-02-28 /pmc/articles/PMC9974110/ /pubmed/36854026 http://dx.doi.org/10.1371/journal.pdig.0000091 Text en © 2023 Peyret et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Peyret, Rémy
Pozin, Nicolas
Sockeel, Stéphane
Kammerer-Jacquet, Solène-Florence
Adam, Julien
Bocciarelli, Claire
Ditchi, Yoan
Bontoux, Christophe
Depoilly, Thomas
Guichard, Loris
Lanteri, Elisabeth
Sockeel, Marie
Prévot, Sophie
Multicenter automatic detection of invasive carcinoma on breast whole slide images
title Multicenter automatic detection of invasive carcinoma on breast whole slide images
title_full Multicenter automatic detection of invasive carcinoma on breast whole slide images
title_fullStr Multicenter automatic detection of invasive carcinoma on breast whole slide images
title_full_unstemmed Multicenter automatic detection of invasive carcinoma on breast whole slide images
title_short Multicenter automatic detection of invasive carcinoma on breast whole slide images
title_sort multicenter automatic detection of invasive carcinoma on breast whole slide images
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974110/
https://www.ncbi.nlm.nih.gov/pubmed/36854026
http://dx.doi.org/10.1371/journal.pdig.0000091
work_keys_str_mv AT peyretremy multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT pozinnicolas multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT sockeelstephane multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT kammererjacquetsoleneflorence multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT adamjulien multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT bocciarelliclaire multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT ditchiyoan multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT bontouxchristophe multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT depoillythomas multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT guichardloris multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT lanterielisabeth multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT sockeelmarie multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages
AT prevotsophie multicenterautomaticdetectionofinvasivecarcinomaonbreastwholeslideimages