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Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide

Herein, Galla Chinensis tannin (GCT) was examined for its influence on preventing lipopolysaccharide (LPS)-induced liver damage in broiler chickens. Approximately 486 one-day-old healthy broilers were randomly allocated to 3 treatment groups (control, LPS, and LPS + GCT). The control and LPS groups...

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Autores principales: Yuan, Peng, Xu, Haitao, Ma, Yuanfei, Niu, Jiaxing, Liu, Yang, Huang, Libo, Jiang, Shuzhen, Jiao, Ning, Yuan, Xuejun, Yang, Weiren, Li, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974168/
https://www.ncbi.nlm.nih.gov/pubmed/36865438
http://dx.doi.org/10.3389/fvets.2023.1126911
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author Yuan, Peng
Xu, Haitao
Ma, Yuanfei
Niu, Jiaxing
Liu, Yang
Huang, Libo
Jiang, Shuzhen
Jiao, Ning
Yuan, Xuejun
Yang, Weiren
Li, Yang
author_facet Yuan, Peng
Xu, Haitao
Ma, Yuanfei
Niu, Jiaxing
Liu, Yang
Huang, Libo
Jiang, Shuzhen
Jiao, Ning
Yuan, Xuejun
Yang, Weiren
Li, Yang
author_sort Yuan, Peng
collection PubMed
description Herein, Galla Chinensis tannin (GCT) was examined for its influence on preventing lipopolysaccharide (LPS)-induced liver damage in broiler chickens. Approximately 486 one-day-old healthy broilers were randomly allocated to 3 treatment groups (control, LPS, and LPS + GCT). The control and LPS groups were fed a basal diet and the LPS+GCT group was fed the basal diet supplemented with 300 mg/kg GCT. LPS was intraperitoneally injected (1 mg/kg body weight BW) in broilers in the LPS and LPS+GCT groups at 17, 19, and 21 days of age. The results manifested that dietary GCT addition attenuated LPS-induced deleterious effects on serum parameters and significantly increased serum immunoglobulin and complement C3 concentrations relative to the control and LPS groups. Dietary supplementation of GCT inhibited LPS-induced increase in broiler hepatic inflammatory cytokines, caspases activities, and TLR4/NF-κB pathway-related gene mRNA expression. Therefore, 300 mg/kg GCT addition to the diet improved the immune function of broilers and inhibit liver inflammation by blocking the TLR4/NF-κB pathway. Our findings provide support for the application of GCT in poultry production.
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spelling pubmed-99741682023-03-01 Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide Yuan, Peng Xu, Haitao Ma, Yuanfei Niu, Jiaxing Liu, Yang Huang, Libo Jiang, Shuzhen Jiao, Ning Yuan, Xuejun Yang, Weiren Li, Yang Front Vet Sci Veterinary Science Herein, Galla Chinensis tannin (GCT) was examined for its influence on preventing lipopolysaccharide (LPS)-induced liver damage in broiler chickens. Approximately 486 one-day-old healthy broilers were randomly allocated to 3 treatment groups (control, LPS, and LPS + GCT). The control and LPS groups were fed a basal diet and the LPS+GCT group was fed the basal diet supplemented with 300 mg/kg GCT. LPS was intraperitoneally injected (1 mg/kg body weight BW) in broilers in the LPS and LPS+GCT groups at 17, 19, and 21 days of age. The results manifested that dietary GCT addition attenuated LPS-induced deleterious effects on serum parameters and significantly increased serum immunoglobulin and complement C3 concentrations relative to the control and LPS groups. Dietary supplementation of GCT inhibited LPS-induced increase in broiler hepatic inflammatory cytokines, caspases activities, and TLR4/NF-κB pathway-related gene mRNA expression. Therefore, 300 mg/kg GCT addition to the diet improved the immune function of broilers and inhibit liver inflammation by blocking the TLR4/NF-κB pathway. Our findings provide support for the application of GCT in poultry production. Frontiers Media S.A. 2023-02-14 /pmc/articles/PMC9974168/ /pubmed/36865438 http://dx.doi.org/10.3389/fvets.2023.1126911 Text en Copyright © 2023 Yuan, Xu, Ma, Niu, Liu, Huang, Jiang, Jiao, Yuan, Yang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Yuan, Peng
Xu, Haitao
Ma, Yuanfei
Niu, Jiaxing
Liu, Yang
Huang, Libo
Jiang, Shuzhen
Jiao, Ning
Yuan, Xuejun
Yang, Weiren
Li, Yang
Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide
title Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide
title_full Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide
title_fullStr Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide
title_full_unstemmed Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide
title_short Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide
title_sort effects of dietary galla chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974168/
https://www.ncbi.nlm.nih.gov/pubmed/36865438
http://dx.doi.org/10.3389/fvets.2023.1126911
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