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Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide
Herein, Galla Chinensis tannin (GCT) was examined for its influence on preventing lipopolysaccharide (LPS)-induced liver damage in broiler chickens. Approximately 486 one-day-old healthy broilers were randomly allocated to 3 treatment groups (control, LPS, and LPS + GCT). The control and LPS groups...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974168/ https://www.ncbi.nlm.nih.gov/pubmed/36865438 http://dx.doi.org/10.3389/fvets.2023.1126911 |
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author | Yuan, Peng Xu, Haitao Ma, Yuanfei Niu, Jiaxing Liu, Yang Huang, Libo Jiang, Shuzhen Jiao, Ning Yuan, Xuejun Yang, Weiren Li, Yang |
author_facet | Yuan, Peng Xu, Haitao Ma, Yuanfei Niu, Jiaxing Liu, Yang Huang, Libo Jiang, Shuzhen Jiao, Ning Yuan, Xuejun Yang, Weiren Li, Yang |
author_sort | Yuan, Peng |
collection | PubMed |
description | Herein, Galla Chinensis tannin (GCT) was examined for its influence on preventing lipopolysaccharide (LPS)-induced liver damage in broiler chickens. Approximately 486 one-day-old healthy broilers were randomly allocated to 3 treatment groups (control, LPS, and LPS + GCT). The control and LPS groups were fed a basal diet and the LPS+GCT group was fed the basal diet supplemented with 300 mg/kg GCT. LPS was intraperitoneally injected (1 mg/kg body weight BW) in broilers in the LPS and LPS+GCT groups at 17, 19, and 21 days of age. The results manifested that dietary GCT addition attenuated LPS-induced deleterious effects on serum parameters and significantly increased serum immunoglobulin and complement C3 concentrations relative to the control and LPS groups. Dietary supplementation of GCT inhibited LPS-induced increase in broiler hepatic inflammatory cytokines, caspases activities, and TLR4/NF-κB pathway-related gene mRNA expression. Therefore, 300 mg/kg GCT addition to the diet improved the immune function of broilers and inhibit liver inflammation by blocking the TLR4/NF-κB pathway. Our findings provide support for the application of GCT in poultry production. |
format | Online Article Text |
id | pubmed-9974168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99741682023-03-01 Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide Yuan, Peng Xu, Haitao Ma, Yuanfei Niu, Jiaxing Liu, Yang Huang, Libo Jiang, Shuzhen Jiao, Ning Yuan, Xuejun Yang, Weiren Li, Yang Front Vet Sci Veterinary Science Herein, Galla Chinensis tannin (GCT) was examined for its influence on preventing lipopolysaccharide (LPS)-induced liver damage in broiler chickens. Approximately 486 one-day-old healthy broilers were randomly allocated to 3 treatment groups (control, LPS, and LPS + GCT). The control and LPS groups were fed a basal diet and the LPS+GCT group was fed the basal diet supplemented with 300 mg/kg GCT. LPS was intraperitoneally injected (1 mg/kg body weight BW) in broilers in the LPS and LPS+GCT groups at 17, 19, and 21 days of age. The results manifested that dietary GCT addition attenuated LPS-induced deleterious effects on serum parameters and significantly increased serum immunoglobulin and complement C3 concentrations relative to the control and LPS groups. Dietary supplementation of GCT inhibited LPS-induced increase in broiler hepatic inflammatory cytokines, caspases activities, and TLR4/NF-κB pathway-related gene mRNA expression. Therefore, 300 mg/kg GCT addition to the diet improved the immune function of broilers and inhibit liver inflammation by blocking the TLR4/NF-κB pathway. Our findings provide support for the application of GCT in poultry production. Frontiers Media S.A. 2023-02-14 /pmc/articles/PMC9974168/ /pubmed/36865438 http://dx.doi.org/10.3389/fvets.2023.1126911 Text en Copyright © 2023 Yuan, Xu, Ma, Niu, Liu, Huang, Jiang, Jiao, Yuan, Yang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Yuan, Peng Xu, Haitao Ma, Yuanfei Niu, Jiaxing Liu, Yang Huang, Libo Jiang, Shuzhen Jiao, Ning Yuan, Xuejun Yang, Weiren Li, Yang Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide |
title | Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide |
title_full | Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide |
title_fullStr | Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide |
title_full_unstemmed | Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide |
title_short | Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide |
title_sort | effects of dietary galla chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974168/ https://www.ncbi.nlm.nih.gov/pubmed/36865438 http://dx.doi.org/10.3389/fvets.2023.1126911 |
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