Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget

Kidney injury in hematologic malignancies can manifest in many ways. We present a case report of a 44-year-old female with de novo acute myeloid leukemia (AML) and acute kidney injury. Following the etiological investigation, lysozyme-induced nephropathy was believed to be the most probable cause of...

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Autores principales: Paulo, Núria, Baptista, Pedro, Nogueira, Fernando, Pereira, Catarina, Cerqueira, Ana, Rocha, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974170/
https://www.ncbi.nlm.nih.gov/pubmed/36865968
http://dx.doi.org/10.7759/cureus.34344
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author Paulo, Núria
Baptista, Pedro
Nogueira, Fernando
Pereira, Catarina
Cerqueira, Ana
Rocha, Ana
author_facet Paulo, Núria
Baptista, Pedro
Nogueira, Fernando
Pereira, Catarina
Cerqueira, Ana
Rocha, Ana
author_sort Paulo, Núria
collection PubMed
description Kidney injury in hematologic malignancies can manifest in many ways. We present a case report of a 44-year-old female with de novo acute myeloid leukemia (AML) and acute kidney injury. Following the etiological investigation, lysozyme-induced nephropathy was believed to be the most probable cause of renal injury. Intensive cytoreduction and chemotherapy were started and the patient's cytopenias and kidney injury have improved. This case highlights the importance of recognizing lysozyme-induced nephropathy as a form of kidney injury in AML. Despite being frequently underrecognized, a precocious diagnosis may impact the patient’s prognosis.
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spelling pubmed-99741702023-03-01 Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget Paulo, Núria Baptista, Pedro Nogueira, Fernando Pereira, Catarina Cerqueira, Ana Rocha, Ana Cureus Internal Medicine Kidney injury in hematologic malignancies can manifest in many ways. We present a case report of a 44-year-old female with de novo acute myeloid leukemia (AML) and acute kidney injury. Following the etiological investigation, lysozyme-induced nephropathy was believed to be the most probable cause of renal injury. Intensive cytoreduction and chemotherapy were started and the patient's cytopenias and kidney injury have improved. This case highlights the importance of recognizing lysozyme-induced nephropathy as a form of kidney injury in AML. Despite being frequently underrecognized, a precocious diagnosis may impact the patient’s prognosis. Cureus 2023-01-29 /pmc/articles/PMC9974170/ /pubmed/36865968 http://dx.doi.org/10.7759/cureus.34344 Text en Copyright © 2023, Paulo et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Paulo, Núria
Baptista, Pedro
Nogueira, Fernando
Pereira, Catarina
Cerqueira, Ana
Rocha, Ana
Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget
title Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget
title_full Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget
title_fullStr Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget
title_full_unstemmed Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget
title_short Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget
title_sort lysozyme-induced nephropathy: a diagnosis not to forget
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974170/
https://www.ncbi.nlm.nih.gov/pubmed/36865968
http://dx.doi.org/10.7759/cureus.34344
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AT pereiracatarina lysozymeinducednephropathyadiagnosisnottoforget
AT cerqueiraana lysozymeinducednephropathyadiagnosisnottoforget
AT rochaana lysozymeinducednephropathyadiagnosisnottoforget

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