lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1

Notch has been implicated in human cancers and is a putative therapeutic target. However, the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore, characterizing the detailed mechanisms governing Notch degradation will identify attractive strategies for treating...

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Detalles Bibliográficos
Autores principales: Zhang, Zhen, Lu, Yun-xin, Liu, Fangzhou, Sang, Lingjie, Shi, Chengyu, Xie, Shaofang, Bian, Weixiang, Yang, Jie-cheng, Yang, Zuozhen, Qu, Lei, Chen, Shi-yi, Li, Jun, Yang, Lu, Yan, Qingfeng, Wang, Wenqi, Fu, Peifen, Shao, Jianzhong, Li, Xu, Lin, Aifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974429/
https://www.ncbi.nlm.nih.gov/pubmed/36795754
http://dx.doi.org/10.1073/pnas.2206694120

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