Cargando…

Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer’s disease

Microglial phagocytosis is an energetically demanding process that plays a critical role in the removal of toxic protein aggregates in Alzheimer’s disease (AD). Recent evidence indicates that a switch in energy production from mitochondrial respiration to glycolysis disrupts this important protectiv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fairley, Lauren H., Lai, Kei Onn, Wong, Jia Hui, Chong, Wei Jing, Vincent, Anselm Salvatore, D’Agostino, Giuseppe, Wu, Xiaoting, Naik, Roshan R., Jayaraman, Anusha, Langley, Sarah R., Ruedl, Christiane, Barron, Anna M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974442/ https://www.ncbi.nlm.nih.gov/pubmed/36787364 http://dx.doi.org/10.1073/pnas.2209177120

Ejemplares similares

Reticulocalbin-1 Facilitates Microglial Phagocytosis
por: Ding, Ying, et al.
Publicado: (2015)

The Role of Microglial Phagocytosis in Ischemic Stroke
por: Jia, Junqiu, et al.
Publicado: (2022)

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis
por: Karlstetter, Marcus, et al.
Publicado: (2014)

Qki is an essential regulator of microglial phagocytosis in demyelination
por: Ren, Jiangong, et al.
Publicado: (2020)

Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease
por: Fairley, Lauren H., et al.
Publicado: (2021)

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
por: Konishi, Hiroyuki, et al.
Publicado: (2020)

Interrogation of human microglial phagocytosis by CRISPR genome editing
por: Chang, Jason Cheng-Yu, et al.
Publicado: (2023)

Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?
por: Janda, Elzbieta, et al.
Publicado: (2018)

CD22 blockade restores homeostatic microglial phagocytosis in aging brains
por: Pluvinage, John V., et al.
Publicado: (2019)

Microglia and CD206(+) border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease
por: Wu, Xiaoting, et al.
Publicado: (2021)

Sweepers in the CNS: Microglial Migration and Phagocytosis in the Alzheimer Disease Pathogenesis
por: Noda, Mariko, et al.
Publicado: (2012)

MFG-E8 Regulates Microglial Phagocytosis of Apoptotic Neurons
por: Fuller, Abby D., et al.
Publicado: (2008)

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
por: Sierra, Amanda, et al.
Publicado: (2013)

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
por: Zhao, Lian, et al.
Publicado: (2015)

Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
por: Nadjar, Agnes, et al.
Publicado: (2017)

Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets
por: Nizami, Sohaib, et al.
Publicado: (2019)

Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis
por: Pinto, Maria V., et al.
Publicado: (2020)

Central nervous system diseases related to pathological microglial phagocytosis
por: Wang, Ke, et al.
Publicado: (2021)

Metabolic regulation of microglial phagocytosis: Implications for Alzheimer's disease therapeutics
por: Lepiarz-Raba, Izabela, et al.
Publicado: (2023)

Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis
por: Zhang, Can, et al.
Publicado: (2018)

Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy
por: Beccari, Sol, et al.
Publicado: (2023)

Cromolyn platform suppresses fibrosis and inflammation, promotes microglial phagocytosis and neurite outgrowth
por: Wang, Yi-Jun, et al.
Publicado: (2021)

Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides(i)
por: Fleisher-Berkovich, Sigal, et al.
Publicado: (2010)

Promotion of microglial phagocytosis by tuftsin stimulates remyelination in experimental autoimmune encephalomyelitis
por: Bao, Zheng, et al.
Publicado: (2019)

Propofol suppresses microglial phagocytosis through the downregulation of MFG-E8
por: Cai, Xiaoying, et al.
Publicado: (2021)

Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer’s disease
por: Desale, Smita Eknath, et al.
Publicado: (2021)

Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons
por: Brown, Guy C.
Publicado: (2021)

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers
por: Xu, Shili, et al.
Publicado: (2018)

Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
por: Ferreira, Raquel, et al.
Publicado: (2011)

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis
por: Neniskyte, Urte, et al.
Publicado: (2014)

Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells
por: Redlich, Sandra, et al.
Publicado: (2013)

Alginate-Derived Oligosaccharide Inhibits Neuroinflammation and Promotes Microglial Phagocytosis of β-Amyloid
por: Zhou, Rui, et al.
Publicado: (2015)

Commentary: CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
por: Wei, Penghui, et al.
Publicado: (2019)

Complement-Mediated Microglial Phagocytosis and Pathological Changes in the Development and Degeneration of the Visual System
por: Borucki, Davis M., et al.
Publicado: (2020)

Promotion of microglial phagocytosis by tuftsin stimulates remyelination inexperimental autoimmune en- cephalomyelitis
por: Bao, Zheng, et al.
Publicado: (2020)

Hexokinase 2 as oncotarget
por: Patra, Krushna C., et al.
Publicado: (2013)

Evidence for contractile protein translocation in macrophage spreading, phagocytosis, and phagolysosome formation
por: Hartwig, JH, et al.
Publicado: (1977)

Inhibition of Bruton’s Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer’s Disease
por: Keaney, James, et al.
Publicado: (2019)

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis
por: Griffin, Percy, et al.
Publicado: (2020)

BK Channel-Mediated Microglial Phagocytosis Alleviates Neurological Deficit After Ischemic Stroke
por: Huang, Shuxian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n11hgtbkctk7i7s8fdmmb92q17