An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

Transcriptional pausing underpins the regulation of cellular RNA synthesis, but its mechanism remains incompletely understood. Sequence-specific interactions of DNA and RNA with the dynamic, multidomain RNA polymerase (RNAP) trigger reversible conformational changes at pause sites that temporarily i...

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Detalles Bibliográficos
Autores principales: Kang, Jin Young, Mishanina, Tatiana V., Bao, Yu, Chen, James, Llewellyn, Eliza, Liu, James, Darst, Seth A., Landick, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974457/
https://www.ncbi.nlm.nih.gov/pubmed/36795753
http://dx.doi.org/10.1073/pnas.2215945120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974457/
https://www.ncbi.nlm.nih.gov/pubmed/36795753
http://dx.doi.org/10.1073/pnas.2215945120

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