A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase

The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal m...

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Detalles Bibliográficos
Autores principales: Dhindwal, Poonam, Thompson, Charis, Kos, Daniel, Planedin, Koa, Jain, Richa, Jelinski, Murray, Ruzzini, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974460/
https://www.ncbi.nlm.nih.gov/pubmed/36791107
http://dx.doi.org/10.1073/pnas.2219827120
Descripción
Sumario:The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.

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