A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase

The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal m...

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Detalles Bibliográficos
Autores principales: Dhindwal, Poonam, Thompson, Charis, Kos, Daniel, Planedin, Koa, Jain, Richa, Jelinski, Murray, Ruzzini, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974460/
https://www.ncbi.nlm.nih.gov/pubmed/36791107
http://dx.doi.org/10.1073/pnas.2219827120
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author Dhindwal, Poonam
Thompson, Charis
Kos, Daniel
Planedin, Koa
Jain, Richa
Jelinski, Murray
Ruzzini, Antonio
author_facet Dhindwal, Poonam
Thompson, Charis
Kos, Daniel
Planedin, Koa
Jain, Richa
Jelinski, Murray
Ruzzini, Antonio
author_sort Dhindwal, Poonam
collection PubMed
description The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.
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spelling pubmed-99744602023-03-02 A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase Dhindwal, Poonam Thompson, Charis Kos, Daniel Planedin, Koa Jain, Richa Jelinski, Murray Ruzzini, Antonio Proc Natl Acad Sci U S A Biological Sciences The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens. National Academy of Sciences 2023-02-15 2023-02-21 /pmc/articles/PMC9974460/ /pubmed/36791107 http://dx.doi.org/10.1073/pnas.2219827120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Dhindwal, Poonam
Thompson, Charis
Kos, Daniel
Planedin, Koa
Jain, Richa
Jelinski, Murray
Ruzzini, Antonio
A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase
title A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase
title_full A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase
title_fullStr A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase
title_full_unstemmed A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase
title_short A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase
title_sort neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974460/
https://www.ncbi.nlm.nih.gov/pubmed/36791107
http://dx.doi.org/10.1073/pnas.2219827120
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