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The circadian demethylation of a unique intronic deoxymethylCpG-rich island boosts the transcription of its cognate circadian clock output gene
We demonstrate that there is a tight functional relationship between two highly evolutionary conserved cell processes, i.e., the circadian clock (CC) and the circadian DNA demethylation–methylation of cognate deoxyCpG-rich islands. We have discovered that every circadian clock-controlled output gene...
Autores principales: | Misra, Nisha, Damara, Manohar, Ye, Tao, Chambon, Pierre |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974474/ https://www.ncbi.nlm.nih.gov/pubmed/36791105 http://dx.doi.org/10.1073/pnas.2214062120 |
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