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Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint

Stringent factors orchestrate bacterial cell reprogramming through increasing the level of the alarmones (p)ppGpp. In Beta- and Gammaproteobacteria, SpoT hydrolyzes (p)ppGpp to counteract the synthetase activity of RelA. However, structural information about how SpoT controls the levels of (p)ppGpp...

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Detalles Bibliográficos
Autores principales:	Tamman, Hedvig, Ernits, Karin, Roghanian, Mohammad, Ainelo, Andres, Julius, Christina, Perrier, Anthony, Talavera, Ariel, Ainelo, Hanna, Dugauquier, Rémy, Zedek, Safia, Thureau, Aurelien, Pérez, Javier, Lima-Mendez, Gipsi, Hallez, Régis, Atkinson, Gemma C., Hauryliuk, Vasili, Garcia-Pino, Abel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974481/ https://www.ncbi.nlm.nih.gov/pubmed/36470996 http://dx.doi.org/10.1038/s41589-022-01198-x

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