Molecular mechanism of GTP binding- and dimerization-induced enhancement of Sar1-mediated membrane remodeling

The Sar1 GTPase initiates coat protein II (COPII)-mediated protein transport by generating membrane curvature at subdomains on the endoplasmic reticulum, where it is activated by the guanine nucleotide exchange factor (GEF) Sec12. Crystal structures of GDP- and GTP-bound forms of Sar1 suggest that i...

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Detalles Bibliográficos
Autores principales: Paul, Sanjoy, Audhya, Anjon, Cui, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974494/
https://www.ncbi.nlm.nih.gov/pubmed/36780528
http://dx.doi.org/10.1073/pnas.2212513120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974494/
https://www.ncbi.nlm.nih.gov/pubmed/36780528
http://dx.doi.org/10.1073/pnas.2212513120

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