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Molecular mechanism of GTP binding- and dimerization-induced enhancement of Sar1-mediated membrane remodeling
The Sar1 GTPase initiates coat protein II (COPII)-mediated protein transport by generating membrane curvature at subdomains on the endoplasmic reticulum, where it is activated by the guanine nucleotide exchange factor (GEF) Sec12. Crystal structures of GDP- and GTP-bound forms of Sar1 suggest that i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974494/ https://www.ncbi.nlm.nih.gov/pubmed/36780528 http://dx.doi.org/10.1073/pnas.2212513120 |