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Modified T(2) Statistics for Improved Detection of Aided Cortical Auditory Evoked Potentials in Hearing-Impaired Infants

The cortical auditory evoked potential (CAEP) is a change in neural activity in response to sound, and is of interest for audiological assessment of infants, especially those who use hearing aids. Within this population, CAEP waveforms are known to vary substantially across individuals, which makes...

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Autores principales: Chesnaye, Michael Alexander, Bell, Steven Lewis, Harte, James Michael, Simonsen, Lisbeth Birkelund, Visram, Anisa Sadru, Stone, Michael Anthony, Munro, Kevin James, Simpson, David Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974628/
https://www.ncbi.nlm.nih.gov/pubmed/36847299
http://dx.doi.org/10.1177/23312165231154035
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author Chesnaye, Michael Alexander
Bell, Steven Lewis
Harte, James Michael
Simonsen, Lisbeth Birkelund
Visram, Anisa Sadru
Stone, Michael Anthony
Munro, Kevin James
Simpson, David Martin
author_facet Chesnaye, Michael Alexander
Bell, Steven Lewis
Harte, James Michael
Simonsen, Lisbeth Birkelund
Visram, Anisa Sadru
Stone, Michael Anthony
Munro, Kevin James
Simpson, David Martin
author_sort Chesnaye, Michael Alexander
collection PubMed
description The cortical auditory evoked potential (CAEP) is a change in neural activity in response to sound, and is of interest for audiological assessment of infants, especially those who use hearing aids. Within this population, CAEP waveforms are known to vary substantially across individuals, which makes detecting the CAEP through visual inspection a challenging task. It also means that some of the best automated CAEP detection methods used in adults are probably not suitable for this population. This study therefore evaluates and optimizes the performance of new and existing methods for aided (i.e., the stimuli are presented through subjects’ hearing aid(s)) CAEP detection in infants with hearing loss. Methods include the conventional Hotellings T(2) test, various modified q-sample statistics, and two novel variants of T(2) statistics, which were designed to exploit the correlation structure underlying the data. Various additional methods from the literature were also evaluated, including the previously best-performing methods for adult CAEP detection. Data for the assessment consisted of aided CAEPs recorded from 59 infant hearing aid users with mild to profound bilateral hearing loss, and simulated signals. The highest test sensitivities were observed for the modified T(2) statistics, followed by the modified q-sample statistics, and lastly by the conventional Hotelling's T(2) test, which showed low detection rates for ensemble sizes <80 epochs. The high test sensitivities at small ensemble sizes observed for the modified T(2) and q-sample statistics are especially relevant for infant testing, as the time available for data collection tends to be limited in this population.
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spelling pubmed-99746282023-03-02 Modified T(2) Statistics for Improved Detection of Aided Cortical Auditory Evoked Potentials in Hearing-Impaired Infants Chesnaye, Michael Alexander Bell, Steven Lewis Harte, James Michael Simonsen, Lisbeth Birkelund Visram, Anisa Sadru Stone, Michael Anthony Munro, Kevin James Simpson, David Martin Trends Hear Original Article The cortical auditory evoked potential (CAEP) is a change in neural activity in response to sound, and is of interest for audiological assessment of infants, especially those who use hearing aids. Within this population, CAEP waveforms are known to vary substantially across individuals, which makes detecting the CAEP through visual inspection a challenging task. It also means that some of the best automated CAEP detection methods used in adults are probably not suitable for this population. This study therefore evaluates and optimizes the performance of new and existing methods for aided (i.e., the stimuli are presented through subjects’ hearing aid(s)) CAEP detection in infants with hearing loss. Methods include the conventional Hotellings T(2) test, various modified q-sample statistics, and two novel variants of T(2) statistics, which were designed to exploit the correlation structure underlying the data. Various additional methods from the literature were also evaluated, including the previously best-performing methods for adult CAEP detection. Data for the assessment consisted of aided CAEPs recorded from 59 infant hearing aid users with mild to profound bilateral hearing loss, and simulated signals. The highest test sensitivities were observed for the modified T(2) statistics, followed by the modified q-sample statistics, and lastly by the conventional Hotelling's T(2) test, which showed low detection rates for ensemble sizes <80 epochs. The high test sensitivities at small ensemble sizes observed for the modified T(2) and q-sample statistics are especially relevant for infant testing, as the time available for data collection tends to be limited in this population. SAGE Publications 2023-02-27 /pmc/articles/PMC9974628/ /pubmed/36847299 http://dx.doi.org/10.1177/23312165231154035 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Chesnaye, Michael Alexander
Bell, Steven Lewis
Harte, James Michael
Simonsen, Lisbeth Birkelund
Visram, Anisa Sadru
Stone, Michael Anthony
Munro, Kevin James
Simpson, David Martin
Modified T(2) Statistics for Improved Detection of Aided Cortical Auditory Evoked Potentials in Hearing-Impaired Infants
title Modified T(2) Statistics for Improved Detection of Aided Cortical Auditory Evoked Potentials in Hearing-Impaired Infants
title_full Modified T(2) Statistics for Improved Detection of Aided Cortical Auditory Evoked Potentials in Hearing-Impaired Infants
title_fullStr Modified T(2) Statistics for Improved Detection of Aided Cortical Auditory Evoked Potentials in Hearing-Impaired Infants
title_full_unstemmed Modified T(2) Statistics for Improved Detection of Aided Cortical Auditory Evoked Potentials in Hearing-Impaired Infants
title_short Modified T(2) Statistics for Improved Detection of Aided Cortical Auditory Evoked Potentials in Hearing-Impaired Infants
title_sort modified t(2) statistics for improved detection of aided cortical auditory evoked potentials in hearing-impaired infants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974628/
https://www.ncbi.nlm.nih.gov/pubmed/36847299
http://dx.doi.org/10.1177/23312165231154035
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