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YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway

Objectives: Dimeric pyruvate kinase (PK) M2 (PKM2) plays an important role in promoting the accumulation of hypoxia-inducible factor (HIF)-1α, mediating aberrant glycolysis and inducing fibrosis in diabetic kidney disease (DKD). The aim of this work was to dissect a novel regulatory mechanism of Yin...

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Detalles Bibliográficos
Autores principales:	Li, Xin, Ma, Tian-Kui, Wang, Min, Zhang, Xiao-Dan, Liu, Tian-Yan, Liu, Yue, Huang, Zhao-Hui, Zhu, Yong-Hong, Zhang, Shuang, Yin, Li, Xu, Yan-Yan, Ding, Hong, Liu, Cong, Shi, Hang, Fan, Qiu-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974832/ https://www.ncbi.nlm.nih.gov/pubmed/36874012 http://dx.doi.org/10.3389/fphar.2023.1069348

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