Supplementation with α-ketoglutarate improved the efficacy of anti-PD1 melanoma treatment through epigenetic modulation of PD-L1

Patients with advanced melanoma have shown an improved outlook after anti-PD1 therapy, but the low response rate restricts clinical benefit; therefore, enhancing anti-PD1 therapeutic efficacy remains a major challenge. Here, our findings showed a significantly increased abundance of α-KG in healthy...

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Detalles Bibliográficos
Autores principales: Liu, Nian, Zhang, Jianglin, Yan, Mingjie, Chen, Lihui, Wu, Jie, Tao, Qian, Yan, Bei, Chen, Xiang, Peng, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974984/
https://www.ncbi.nlm.nih.gov/pubmed/36854755
http://dx.doi.org/10.1038/s41419-023-05692-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974984/
https://www.ncbi.nlm.nih.gov/pubmed/36854755
http://dx.doi.org/10.1038/s41419-023-05692-5

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