TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN

We report herein that TSPAN32 is a key node factor for Philadelphia (Ph(+)) leukemia pathogenesis. We found that TSPAN32 expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment inhibited the proliferation of Ph(+) cell lines. Tspan32 overexpression significantly pr...

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Detalles Bibliográficos
Autores principales: Qiu, Qiang, Sun, Yuanyuan, Yang, Linyu, Li, Qingqing, Feng, Yunyu, Li, Mengyuan, Yin, Yuexia, Zheng, Li, Li, Ning, Qiu, Huandi, Cui, Xue, He, Wei, Wang, Bochuan, Pan, Cong, Wang, Zi, Huang, Juan, Sample, Klarke M., Li, Zhihui, Hu, Yiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974991/
https://www.ncbi.nlm.nih.gov/pubmed/36854750
http://dx.doi.org/10.1038/s41392-022-01290-7

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