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Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly understood. Here, we report molecular level details and structural mechanisms of PP2A-B56α inhibition by an oncoprotein CIP2A. Upon direc...

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Detalles Bibliográficos
Autores principales:	Pavic, Karolina, Gupta, Nikhil, Omella, Judit Domènech, Derua, Rita, Aakula, Anna, Huhtaniemi, Riikka, Määttä, Juha A., Höfflin, Nico, Okkeri, Juha, Wang, Zhizhi, Kauko, Otto, Varjus, Roosa, Honkanen, Henrik, Abankwa, Daniel, Köhn, Maja, Hytönen, Vesa P., Xu, Wenqing, Nilsson, Jakob, Page, Rebecca, Janssens, Veerle, Leitner, Alexander, Westermarck, Jukka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974998/ https://www.ncbi.nlm.nih.gov/pubmed/36854761 http://dx.doi.org/10.1038/s41467-023-36693-9

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