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Reciprocal causation mixture model for robust Mendelian randomization analysis using genome-scale summary data

Mendelian randomization using GWAS summary statistics has become a popular method to infer causal relationships across complex diseases. However, the widespread pleiotropy observed in GWAS has made the selection of valid instrumental variables problematic, leading to possible violations of Mendelian...

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Detalles Bibliográficos
Autores principales:	Liu, Zipeng, Qin, Yiming, Wu, Tian, Tubbs, Justin D., Baum, Larry, Mak, Timothy Shin Heng, Li, Miaoxin, Zhang, Yan Dora, Sham, Pak Chung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975185/ https://www.ncbi.nlm.nih.gov/pubmed/36854672 http://dx.doi.org/10.1038/s41467-023-36490-4

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